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In this PhD activity you will be alive on imaging of allowed corpuscle aggression in the bump with account to altered allowed inhibitory factors present in the bump micro-environment.An important allowed suppressive agency is hypoxia. Hypoxia in blight is amenable for the alternative of awful advancing blight beef that survive beneath hypoxic altitude and it protects blight beef from aishment by the allowed system.

Part of this activity is the in vivo appraisal of hypoxia in the cartilage bottom of assorted myeloma patients by PET-CT based hypoxia imaging and acceptance by immunohistochemical assay of cartilage bottom biopsies from MM patients.

In accession to this ytic imaging in MM patients we accept set out to advance a pre-clinical in vivo non-invasive nanobody-based imaging action to ascertain allowed corpuscle aggression in affiliation to altered immunosuppressive factors of the bump micro-environment. For these pre-clinical stus we will accomplish use of absolute solid bump as able-bod as hematological bump beastly models.

Nanobos, additionally accepted as distinct abundant alternation alone antibos (VHHs), are baby (15kDa) antibiotic bits consisting of a distinct monomeric capricious antibiotic area and thereby anchorage the aing antigen-binding capacity. They are engineered from distinct abundant chain-only antibos that artlessly action in camelids. Nanobos are about 10 times abate than accepted

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